Time & Location
Autumn Quarter 2014
1.5 credits, weeks 6-10 (Oct 30 - Dec 4)
Tuesdays and Thursdays
Place: FHCRC B1-072-074
A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).
Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).
Lectures will be ready for downloading the day after the lecture and can also be found in eReserves.
A copy of the entire lecture schedule is available for download below.
Lecture 1 - Oct 30, 2014
Transcriptional Regulatory Mechanisms in Prokaryotes
Lecture 2 - Nov 4, 2014
Mechanisms of RNA Polymerase II initiation and elongation
Lecture 3 - Nov 6, 2014
Eukaryotic promoters, enhancers and other regulatory elements
Lecture 4 - Nov 13, 2014
Enhancers, coactivators and transcription activation mechanisms
Homework#1 to be handed out.
Lecture 5 - Nov 18, 2014
Chromatin and Transcription: General Overview
Lecture 6 - Nov 20, 2014
Histone Modifying Enzymes
Lecture 7 - Nov 25, 2014
ATP-dependent Chromatin Remodeling Factors
Homework #1 due
Homework #2 to be handed out
lecture 8 - Dec 2, 2014
Promoter-specific and Regional Regulation of Transcription
Homework #1 to be returned
Lecture 9 - Dec 4, 2014
Dynamic and Compex Patterns of Gene Expression
Homework #2 due
Homework #3 handed out (due Dec 11 and can be dropped off at Mailstop C3-168 or emailed to firstname.lastname@example.org.
Homework #2 and #3 can be picked up after 12/11 (#2) and 12/17 (#3) at A1-175 (#2) and C3-168 (#3).