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Conj 537 - Mechanisms of Transcriptional Regulation  

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription.
Last Updated: Oct 21, 2014 URL: Print Guide RSS UpdatesEmail Alerts

Class Schedule Print Page

Time & Location

Autumn Quarter 2014

1.5 credits, weeks 6-10 (Oct 30 - Dec 4)

Tuesdays and Thursdays

Times: 3:20-4:40

Place: FHCRC B1-072-074


Course Description

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).


Lecture Schedule

Lecture dates, topics and lecturer are listed below. Copies of all the readings are available in the eReserves (select the tab above).

Lectures will be ready for downloading the day after the lecture and can also be found in eReserves.

A copy of the entire lecture schedule is available for download below.


    Lecture 1 - Oct 30, 2014

    Transcriptional Regulatory Mechanisms in Prokaryotes
    Steve Hahn


    Lecture 2 - Nov 4, 2014

    Paper discussion and lecture on RNA Pol II Transcription and Regulation I
    Steve Hahn


    Lecture 3 - Nov 6, 2014

    Paper discussion and RNA Pol II Transcription and Regulation II
    Steve Hahn


    Lecture 4 - Nov 13, 2014

    Paper discussion and Transcriptional Activation Mechanisms
    Steve Hahn

    Homework#1 to be handed out.


    Lecture 5 - Nov 18, 2014

    Chromatin and Transcription: General Overview
    Toshi Tsukiyama


    Lecture 6 - Nov 20, 2014

    Histone Modifying Enzymes
    Toshi Tsukiyama

    Homework #1 due


    Lecture 7 - Nov 25, 2014

    ATP-dependent Chromatin Remodeling Factors
    Toshi Tsukiyama

    Homework #2 to be handed out



    lecture 8 - Dec 2, 2014

    Promoter-specific and Regional Regulation of Transcription
    Steve Tapscott

    Homework #1 to be returned


    Lecture 9 - Dec 4, 2014

    Dynamic and Compex Patterns of Gene Expression
    Steve Tapscott

    Homework #2 due

    Homework #3 handed out (due Dec 11 and can be dropped off at Mailstop C3-168 or emailed to

    Homework #2 and #3 can be picked up after 12/11 (#2) and 12/17 (#3) at A1-175 (#2) and C3-168 (#3).

    Subject Guide

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    Contact Info
    Mailstop: B1-010
    phone: x.4314
    fax: x.4737
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    Course Organizer

    Course Organizer:

    Toshio Tsukiyama, Ph.D.

    Additional Lecturers:

    Steve Hahn

    Steve Tapscott


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