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Write a critical review of two of following four topics. Include critical background data, limitations of what is known, and more importantly what is not known. Identify key experiments you might propose to do to support or disprove the concept. About two pages each should be sufficient. Be concise.
On 3 June we will form into four groups according to each topic and each group will have 20-30 minutes to discuss each topic. Everyone will be required to orally argue their case for or against.
Topic 1: DNA damage-induced senescence as a barrier to
cancer.
Topic 2: The role of epigenetics in cancer.
Topic 3: Mutator phenotype and cancer.
Topic 4: Stem cells and cancer
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Lecture 1 - 5/6/08 - Chris Kemp
RAS and p53
Lecture 2 - 5/8/08 - Chris Kemp
Inherited susceptibility and tumor suppressor genes
Lecture 3 - 5/13/08 - William Grady
Genetic and epigenetic alterations in colon cancer
Epigenetic Changes in Solid and Hematopoietic Tumors.
Toyota, M. and Issa, J-P. (2005) Seminars in Oncology 32:521.
Note: This article is available only in print from FHCRC and UW libraries. Please go to the library to xerox a copy.
Lecture 4 - 5/15/08 - Valeri Vasioukhin
Cell adhesion / Wnt signaling
Lecture 5 - 5/20/08 - Norm Greenberg
Prostate cancer: from mice to men
Lecture 6 - 5/22/08 - Carla Grandori
Oncogene networks to identify cancer targets
Lecture 7 - 5/27/08 - Brian Reid
Evolution of Barrett's esophageal cancer
Lecture 8 - 5/29/08 - Toshi Taniguchi
BRCA1/2 and chemotherapy
Lecture 10 - 6/5/08 - Peggy Porter
Pathology and genomics in breast cancer
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William Grady - wgrady@fhcrc.org
Carla Grandori - cgrandor@fhcrc.org
Norman Greenberg - ngreenberg@fhcrc.org
Chris Kemp - cjkemp@fhcrc.org
Peggy Porter - pporter@fhcrc.org
Brian Reid - bjr@fhcrc.org
Toshi Tanaguchi - ttaniguc@fhcrc.org
Valeri Vasioukhin - vvasiouk@fhcrc.org
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