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MCB 539 Biological Basis of Neoplasia   Tags: conj539, neoplasia, taniguchi, vasioukhin  

MCB 539 MCB program Core Course Module Spring Quarter: April 2 - June 4, 2015
Last Updated: Mar 6, 2015 URL: http://libguides.fhcrc.org/neoplasia Print Guide RSS UpdatesEmail Alerts

Lecture Schedule Print Page
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Time & Location

April 2 - June 4, 2015
Tuesday and Thursday

3:20-4:40 p.m.
FHCRC Weintraub bldg
Room B1-072/074

 

Course Textbook

Cover Art
The Biology of Cancer - Robert A. Weinberg
Call Number: QZ 202 W423b 2014
ISBN: 9780815342205
Publication Date: 2013-05-16

Recommended Readings

The Emperor of all Maladies by Siddhartha Mukherjee

The Molecular Basis of Cancer by John Mendelsohn MD et al.


  • Nature Milestones in Cancer
    The Milestones are a series of specially written articles, which highlight the most influential discoveries in the field of cancer over the past century. Milestones in Cancer also comprises a Collection of selected review-type articles and an online-only NPG library of recent research papers and review content organized according to contributing journal.
  • Nature Reviews Cancer
 

Conj 539 Course Description

This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis.

The latest state of the art research in Cancer Biology will be presented by invited scientists, experts in their relevant field. The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.  (3 credits)

Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

Enrollment in the course is limited to 20 students.

 

Lecture 1 - April 2, 2015

Introduction: Genetic basis of cancer

Valera Vasioukhin

Readings (copies available in eReserves)

Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674

The Biology of Cancer. Weinberg (on reserve in Arnold Library)

     

    Lecture 2 - April 7, 2015

    Oncogenes

    Valera Vasioukhin

    Readings (copies available in eReserves)

    Hallmarks of Cancer: The Next Generation
    Hanahan, D. and Weinberg, R.
    Cell 2011;144(5): 646-674

    The Biology of Cancer. Weinberg (on reserve in Arnold Library)

       

      Lecture 3 - April 9, 2015

      Tumor Suppressors

      Toshiyasu Taniguchi

      Readings (copies available in eReserves)

      Hallmarks of Cancer: The Next Generation
      Hanahan, D. and Weinberg, R.
      Cell 2011;144(5): 646-674

      The Biology of Cancer. Weinberg (on reserve in Arnold Library)

         

        Lecture 4 - April 14, 2015

        Myc Oncogene

        Bob Eisenman

        Reading (copies available in eReserves)

        REVIEW: Conacci-Sorrell M, McFerrin L, Eisenman RN. An overview of MYC and its interactome. Cold Spring Harb Perspect Med 2014;4(1):a014357.

        RESEARCH PAPER: Lin CY, Loven J, Rahl PB, Paranal RM, Burge CB, Bradner JE, et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 2012;151(1):56-67.

        (This paper will be presented in a student-led literature review session on May 15, Thursday)

           

          Lecture 5 - April 16, 2015

          Molecular Basis of Cancer Therapy and Resistance

          Toshiyasu Taniguchi

          Readings (copies available in eReserves)

          Hallmarks of Cancer: The Next Generation
          Hanahan, D. and Weinberg, R.
          Cell 2011;144(5): 646-674

          The Biology of Cancer. Weinberg (on reserve in Arnold Library)

             

            Lecture 6 -April 21, 2015

            Molecular Pathogenesis of Colorectal Cancer

            Bill Grady

            Readings (copies available in eReserves)

            REVIEW: Roper J, Hung KE. Molecular Mechanisms of Colorectal Carcinogenesis. In: Haigis KM, editor. Molecular Pathogenesis of Colorectal Cancer; 2013. p. 25-65.

            RESEARCH PAPER: Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457(7229):608-11.

            (This paper will be presented in a student-led literature review session on June 3)

               

              Lecture 7 - April 23, 2015

              Literature Review 1, Colorectal Cancer

              REVIEW:  Roper J, Hung KE. Molecular Mechanisms of Colorectal Carcinogenesis. In: Haigis KM, editor. Molecular Pathogenesis of Colorectal Cancer; 2013. p. 25-65.

              RESEARCH PAPER:  Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457(7229):608-11.

                 

                Lecture 8 - April 28, 2015

                Metastasis

                Cyrus Ghajar

                Readings (copies available in eReserves)

                REVIEW: Vanharanta S, Massague J. Origins of metastatic traits. Cancer Cell 2013;24(4):410-21.

                RESEARCH PAPER:  Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012;18(6):883-91.

                (This paper will be presented in a student-led literature review session on May 13, Tuesday.)

                   

                  Lecture 9 - April 30, 2015

                  Lung Cancer and Rb

                  David MacPherson

                  Readings (copies available in eReserves)

                  REVIEW: Kwon MC, Berns A. Mouse models for lung cancer. Mol Oncol 2013;7(2):165-77.

                     

                    Lecture 10 - May 5, 2015

                    Literature Review 2, Lung Cancer

                    REVIEW: Kwon MC, Berns A. Mouse models for lung cancer. Mol Oncol 2013;7(2):165-77.

                    RESEARCH PAPER: Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, et al. The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 2013;23(4):527-40.

                     

                       

                      Lecture 11 - May 7, 2015

                      Molecular basis of brain tumors and new approaches to their treatment

                      Eric Holland

                      Readings (copies available in eReserves)

                      REVIEW: Sturm D, Bender S, Jones DT, Lichter P, Grill J, Becher O, Hawkins C, Majewski J, Jones C, Costello JF, Iavarone A, Aldape K, Brennan CW, Jabado N, Pfister SM. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer. 2014 Feb;14(2):92-107. doi: 10.1038/nrc3655. Review. PMID: 24457416.

                         

                        Lecture 12 - May 12, 2015

                        Hematopoetic Malignancies

                        Jerry Radich

                        Readings (copies available in eReserves)

                        REVIEW:  Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011;29(5):475-86.

                        RESEARCH PAPER:

                        Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, et al. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med 2013;368(19):1781-90.

                        Anderson K, Lutz C, van Delft FW, Bateman CM, Guo Y, Colman SM, et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 2011;469(7330):356-61.

                        Haibe-Kains B, El-Hachem N, Birkbak NJ, Jin AC, Beck AH, Aerts HJ, et al. Inconsistency in large pharmacogenomic studies. Nature 2013;504(7480):389-93.

                           

                          Lecture 13 - May 14, 2015

                          HPV and squamous cell carcinoma

                          Denise Galloway

                          Readings (copies available in eReserves)

                          REVIEW: Gillison ML, Castellsague X, Chaturvedi A, Goodman MT, Snijders P, Tommasino M, Arbyn M, Franceschi S. Eurogin Roadmap: comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix. Int J Cancer 2014;134(3):497-507.

                          RESEARCH PAPER:  McLaughlin-Drubin ME, Park D, Munger K. Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines. Proc Natl Acad Sci U S A 2013;110(40):16175-80.

                             

                            Lecture 14 - May 19, 2015

                            Pancreatic Cancer

                            Sunil Hingorani

                            Readings (copies available in eReserves)

                            REVIEW: Hingorani SR, Potter JD. Pancreas cancer meets the thunder god. Sci Transl Med 2012;4(156):156ps21.

                            RESEARCH PAPER: Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012;21(3):418-29.

                             

                               

                              Lecture 15 - May 21, 2015

                              Literature Review 3, Myc Oncogene

                              RESEARCH PAPER:  Sabò A, Kress TR, Pelizzola M, de Pretis S, Gorski MM, Tesi A, Morelli MJ, Bora P, Doni M, Verrecchia A, Tonelli C, Fagà G, Bianchi V, Ronchi A, Low D, Müller H, Guccione E, Campaner S, Amati B. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature. 2014 Jul 24;511(7510):488-92. doi: 10.1038/nature13537. Epub 2014 Jul 9.

                               

                                 

                                Lecture 16 - May 26, 2015

                                Regulation of protein synthesis in tumor initiation and progressions

                                Andrew Hsieh

                                Readings

                                Review: Silvera, D., Formenti, S. C., & Schneider, R. J. (2010). Translational control in cancer. Nature Reviews Cancer, 10(4), 254–266. doi:10.1038/nrc2824

                                RESEARCH PAPER:  Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22;485(7396):55-61. doi: 10.1038/nature10912. PMID: 22367541.

                                   

                                  Lecture 17 - May 28, 2015

                                  Helicobacter pylori and Gastric Cancer

                                  Nina Salama

                                  Readings (copies available in eReserves)

                                  REVIEW: Salama NR, Hartung ML, Muller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol 2013;11(6):385-99.

                                  RESEARCH PAPER: Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, et al. Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. Cell Host Microbe 2012;12(6):764-77

                                   

                                     

                                    Lecture 18 - June 2, 2015

                                    Literature Review 4, Cancer Metastasis

                                    REVIEW: Vanharanta S, Massagué J. Origins of metastatic traits. Cancer Cell. 2013 Oct 14;24(4):410-21. doi: 10.1016/j.ccr.2013.09.007. PMID: 24135279

                                    RESEARCH PAPER: Gao H1, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, Shen R, Brogi E, Brivanlou AH, Giancotti FG., The BMP inhibitor Coco reactivates breast cancer cells at lung metastaticsites. Cell. 2012 Aug 17;150(4):764-79. doi: 10.1016/j.cell.2012.06.035.

                                       

                                      Lecture 19 - June 4, 2014

                                      Literature Review #4

                                      REVIEW: Sturm D, Bender S, Jones DT, Lichter P, Grill J, Becher O, Hawkins C, Majewski J, Jones C, Costello JF, Iavarone A, Aldape K, Brennan CW, Jabado N, Pfister SM. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer. 2014 Feb;14(2):92-107. doi: 10.1038/nrc3655. Review. PMID: 24457416.

                                      RESEARCH PAPER: Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, DeBerardinis RJ, Tu BP, Maher EA, Bachoo RM. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell. 2014 Dec 18;159(7):1603-14. doi: 10.1016/j.cell.2014.11.025.

                                         

                                        Course Instructors

                                        Course organizers

                                        Valera Vasioukhin
                                        vvasiouk@fhcrc.org

                                        Toshi Taniguchi
                                        ttaniguc@fhcrc.org

                                        Lecturers

                                        Bob Eisenman
                                        eisenman@fhcrc.org

                                        Denise Galloway
                                        dgallowa@fhcrc.org

                                        Cyrus Ghajar
                                        cghajar@fhcrc.org

                                        Bill Grady
                                        wgrady@fhcrc.org

                                        Sunil Hingorani
                                        srh@fhcrc.org

                                        Eric Holland
                                        eholland@fredhutch.org

                                        Andrew Hsieh
                                        ahsieh@fredhutch.org

                                        David MacPherson
                                        dmacpher@fhrc.org

                                        Jerry Radich
                                        jradich@fhcrc.org

                                        Nina Salama
                                        nsalama@fhcrc.org

                                         

                                         

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