Conj 539 Biological Basis of Neoplasia   Tags: conj539, neoplasia, vasioukhin  

April 2 - June 6, 2013
Tuesday and Thursday
3:20-4:40 p.m.
FHCRC Weintraub bldg
Room B1-072/074

The Emperor of all Maladies by Siddhartha Mukherjee

The Molecular Basis of Cancer by John Mendelsohn MD et al.

This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis.

The latest state of the art research in Cancer Biology will be presented by invited scientists, experts in their relevant field. The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.  (3 credits)

Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

Enrollment in the course is limited to 20 students.

Introduction: Genetic basis of cancer
Valera Vasioukhin

Readings (copies available in eReserves)

Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674

The Biology of Cancer. Weinberg (on reserve in Arnold Library)

Oncogenes
Valera Vasioukhin

Readings (copies available in eReserves)

Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674

The Biology of Cancer. Weinberg (on reserve in Arnold Library)

Tumor Suppressors
Toshi Taniguchi

Readings (copies available in eReserves)

Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674

The Biology of Cancer. Weinberg (on reserve in Arnold Library)

Molecular Basis of Cancer Therapy and Resistance
Toshi Taniguchi

Readings (copies available in eReserves)

Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674

The Biology of Cancer. Weinberg (on reserve in Arnold Library)

Prostate Cancer

Peter Nelson

Readings (copies available in eReserves)

Molecular genetics of prostate cancer: new prospects for old challenges.
Shen and Abate-Shen.
Genes Dev 2010; 24 (18): 1967-2000

Presentation and discussion of research paper on prostate cancer

Reading (copies available in eReserves)

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer.
Carver et al
Cancer Cell 2011;19(5): 575-586

HPV and squamous cell carcinoma
Denise Galloway

Readings (copies available in eReserves)

The natural history of cervical HPV infection: unresolved issues
Woodman et al
Nature Reviews. Cancer 2007;7(1): 11-22

Presentation and discussion of research paper on skin cancer

Readings (copies available in eReserves)

Nucleotide deficiency promotes genomic instability in early stages of cancer development
Bester et al
Cell 2011; 145(3): 435-446

Molecular Pathogenesis of Colorectal Cancer

Bill Grady

Readings (copies available in eReserves)

Chapter 3 CRC Molecular Pathology: The Genetics of Colorectal Cancer.
Kas and Grady (copy in eReserves only)

Presentation and discussion of research paper on colorectal cancer

Readings (copies available in eReserves)

Suppresion of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling.
Sonochita et al
Cancer Cell 2011;19(1): 125 -137

MicroRNAs and cancer
Muneesh Tewari

Readings (copies available in eReserves)

miRNAs in human cancer
Farazi et al
J. Pathol. 2011;223(2): 102-115

Presentation and Discussion of Research Paper on microRNAs in Cancer

Readings (copies available in eReserves)

Impaired microRNA processing enhances cellular transformation and tumorigenesis.
Kumar et al
Nature Genetics 2007; 39 (5):673-677

Hemotopoietic Malignancies

Jerry Radich

Readings (copies available in eReserves)

Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications.
Marcucci, Haferlach and Donher
Journal of Clinical Oncology 2011; 29 (5): 475-487

Presentation and Discussion of Research Paper on Hematopoietic cancer

Readings (copies available in eReserves)

The Origin and Evolution of Mutations in Acute Myeloid Leukemia
Welch et al
Cell 2012; 150, 264-278

Pancreatic Cancer

Sunil Hingorani

Readings (copies available in eReserves)

Pancreatic Cancer
Vincent, et al
Lancet 2011; 378:607-620

Presentation and Discussion of research paper on pancreatic cancer

Readings (copies available in eReserves)

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma.
Provenzano, et al
Cancer Cell 2012, 21: 418-429

Cell cycle control and ubiquitin-mediated proteolysis
Bruce Clurman

Readings (copies available in eReserves)

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
Welcker M, Clurman BE.   
Nat Rev Cancer. 2008 Feb;8(2):83-93. Review.

The ubiquitin proteasome system - Implications for cell cycle control and the targeted treatment of cancer.
Bassermann F, Eichner R, Pagano M.
Biochim Biophys Acta. 2013 http://dx.doi.org/10.1016/j.bbamcr.2013.02.028

Presentation and Discussion of research paper on cell cycle control in cancer

Readings (copies available in eReserves)

Ablation of  Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence.
Takeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A, Nakayama KI.
Cancer Cell 2013 Mar 18;23(3):347-61.

Regulation of c-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression.
Reavie L, Buckley SM, Loizou E, Takeishi S, Aranda-Orgilles B, Ndiaye-Lobry D, Abdel-Wahab O, Ibrahim S, Nakayama KI, Aifantis I.
Cancer Cell 2013 Mar 18; 23(3): 362 -75

Mutator phenotype: Nuclear and mitochondrial mutations in carcinogenesis
Jason Bielas

Readings (copies available in eReserves)

Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer
Kulawiec, et al
Environ Mol Mutagen 2010 51(5): 427-439  (copy in eReserves only)

Presentation and discussion of research paper on role of mutations in human cancer

Readings (copies available in eReserves)

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis  
Kaori Ishikawa, et al
Science 2008;320(5876): 661-664

supplemental data for Ishikawa et al
DOI: 10.1126/science.1156906

Course organizers

Valera Vasioukhin
vvasiouk@fhcrc.org

Toshi Taniguchi
ttaniguc@fhcrc.org

Lecturers

Peter Nelson
pnelson@fhcrc.org

Denise Galloway
dgallowa@fhcrc.org

Bill Grady
wgrady@fhcrc.org

Muneesh Tewari
mtewari@fhcrc.org

Jerry Radich
jradich@fhcrc.org

Sunil Hingorani
srh@fhcrc.org

Bruce Clurman
bclurman@fhcrc.org

Jason Bielas
jbielas@fhcrc.org