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Conj 539 Biological Basis of Neoplasia   Tags: conj539, neoplasia, taniguchi, vasioukhin  

Conjoint 539 MCB program Core Course Module Spring Quarter: April 1 - June 5, 2014
Last Updated: Jan 12, 2015 URL: http://libguides.fhcrc.org/neoplasia Print Guide RSS UpdatesEmail Alerts

Lecture Schedule Print Page
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Time & Location

April 2 - June 4, 2015
Tuesday and Thursday

3:20-4:40 p.m.
FHCRC Weintraub bldg
Room B1-072/074

 

Course Textbook

Cover Art
The Biology of Cancer - Robert A. Weinberg
Call Number: QZ 202 W423b 2014
ISBN: 9780815342205
Publication Date: 2013-05-16

Recommended Readings

The Emperor of all Maladies by Siddhartha Mukherjee

The Molecular Basis of Cancer by John Mendelsohn MD et al.


  • Nature Milestones in Cancer
    The Milestones are a series of specially written articles, which highlight the most influential discoveries in the field of cancer over the past century. Milestones in Cancer also comprises a Collection of selected review-type articles and an online-only NPG library of recent research papers and review content organized according to contributing journal.
  • Nature Reviews Cancer
 

Conj 539 Course Description

This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis.

The latest state of the art research in Cancer Biology will be presented by invited scientists, experts in their relevant field. The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.  (3 credits)

Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

Enrollment in the course is limited to 20 students.

 

Lecture 1 - April 2, 2015

Introduction: Genetic basis of cancer

Valera Vasioukhin

Readings (copies available in eReserves)

Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674

The Biology of Cancer. Weinberg (on reserve in Arnold Library)

     

    Lecture 2 - April 7, 2015

    Oncogenes

    Valera Vasioukhin

    Readings (copies available in eReserves)

    Hallmarks of Cancer: The Next Generation
    Hanahan, D. and Weinberg, R.
    Cell 2011;144(5): 646-674

    The Biology of Cancer. Weinberg (on reserve in Arnold Library)

       

      Lecture 3 - April 9, 2015

      Tumor Suppressors

      Toshiyasu Taniguchi

      Readings (copies available in eReserves)

      Hallmarks of Cancer: The Next Generation
      Hanahan, D. and Weinberg, R.
      Cell 2011;144(5): 646-674

      The Biology of Cancer. Weinberg (on reserve in Arnold Library)

         

        Lecture 4 - April 14, 2015

        Molecular Basis of Cancer Therapy and Resistance

        Toshiyasu Taniguchi

        Readings (copies available in eReserves)

        Hallmarks of Cancer: The Next Generation
        Hanahan, D. and Weinberg, R.
        Cell 2011;144(5): 646-674

        The Biology of Cancer. Weinberg (on reserve in Arnold Library)

           

          Lecture 5 - April 16, 2015

          Myc Oncogene

          Bob Eisenman

          Reading (copies available in eReserves)

          REVIEW: Conacci-Sorrell M, McFerrin L, Eisenman RN. An overview of MYC and its interactome. Cold Spring Harb Perspect Med 2014;4(1):a014357.

          RESEARCH PAPER: Lin CY, Loven J, Rahl PB, Paranal RM, Burge CB, Bradner JE, et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 2012;151(1):56-67.

          (This paper will be presented in a student-led literature review session on May 15, Thursday)

             

            Lecture 6 -April 21, 2015

            Molecular Pathogenesis of Colorectal Cancer

            Bill Grady

            Readings (copies available in eReserves)

            REVIEW: Roper J, Hung KE. Molecular Mechanisms of Colorectal Carcinogenesis. In: Haigis KM, editor. Molecular Pathogenesis of Colorectal Cancer; 2013. p. 25-65.

            RESEARCH PAPER: Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457(7229):608-11.

            (This paper will be presented in a student-led literature review session on June 3)

               

              Lecture 7 - April 23, 2015

               

              Lecture 8 - April 28, 2015

              Metastasis

              Cyrus Ghajar

              Readings (copies available in eReserves)

              REVIEW: Vanharanta S, Massague J. Origins of metastatic traits. Cancer Cell 2013;24(4):410-21.

              RESEARCH PAPER:  Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012;18(6):883-91.

              (This paper will be presented in a student-led literature review session on May 13, Tuesday.)

                 

                Lecture 9 - April 30, 2015

                Lung Cancer and Rb

                David MacPherson

                Readings (copies available in eReserves)

                REVIEW: Kwon MC, Berns A. Mouse models for lung cancer. Mol Oncol 2013;7(2):165-77.

                RESEARCH PAPER: Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, et al. The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 2013;23(4):527-40.

                (This paper will be presented in a student-led literature review session on June 5.)

                   

                  Lecture 10 - May 5, 2015

                   

                  Lecture 11 - May 7, 2015

                  Molecular basis of brain tumors and new approaches to their treatment

                  Eric Holland

                  Readings (copies available in eReserves)

                   

                     

                    Lecture 12 - May 12, 2015

                    Hematopoetic Malignancies

                    Jerry Radich

                    Readings (copies available in eReserves)

                    REVIEW:  Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011;29(5):475-86.

                    RESEARCH PAPER:

                    Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, et al. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med 2013;368(19):1781-90.

                    Anderson K, Lutz C, van Delft FW, Bateman CM, Guo Y, Colman SM, et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 2011;469(7330):356-61.

                    Haibe-Kains B, El-Hachem N, Birkbak NJ, Jin AC, Beck AH, Aerts HJ, et al. Inconsistency in large pharmacogenomic studies. Nature 2013;504(7480):389-93.

                       

                      Lecture 13 - May 14, 2015

                      HPV and squamous cell carcinoma

                      Denise Galloway

                      Readings (copies available in eReserves)

                      REVIEW: Gillison ML, Castellsague X, Chaturvedi A, Goodman MT, Snijders P, Tommasino M, Arbyn M, Franceschi S. Eurogin Roadmap: comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix. Int J Cancer 2014;134(3):497-507.

                      RESEARCH PAPER:  McLaughlin-Drubin ME, Park D, Munger K. Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines. Proc Natl Acad Sci U S A 2013;110(40):16175-80.

                         

                        Lecture 14 - May 19, 2015

                        Pancreatic Cancer

                        Sunil Hingorani

                        Readings (copies available in eReserves)

                        REVIEW: Hingorani SR, Potter JD. Pancreas cancer meets the thunder god. Sci Transl Med 2012;4(156):156ps21.

                        RESEARCH PAPER: Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012;21(3):418-29.

                         

                           

                          Lecture 15 - May 21, 2015

                           

                          Lecture 16 - May 26, 2015

                          Regulation of protein synthesis in tumor initiation and progressions

                          Andrew Hsieh

                          Readings

                             

                            Lecture 17 - May 28, 2015

                            Helicobacter pylori and Gastric Cancer

                            Nina Salama

                            Readings (copies available in eReserves)

                            REVIEW: Salama NR, Hartung ML, Muller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol 2013;11(6):385-99.

                            RESEARCH PAPER: Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, et al. Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. Cell Host Microbe 2012;12(6):764-77

                             

                               

                              Lecture 18 - June 2, 2015

                               

                              Lecture 19 - June 4, 2014

                              Literature Review #4

                              Bill Grady's choice (colorectal cancer)

                              Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457(7229):608-11.

                                 

                                Lecture 20 - June 5, 2014

                                Paper

                                 

                                   

                                  Course Instructors

                                  Course organizers

                                  Valera Vasioukhin
                                  vvasiouk@fhcrc.org

                                  Toshi Taniguchi
                                  ttaniguc@fhcrc.org

                                  Lecturers

                                  Jason Bielas
                                  jbielas@fhcrc.org

                                  Bruce Clurman
                                  bclurman@fhcrc.org

                                  Bob Eisenman
                                  eisenman@fhcrc.org

                                  Denise Galloway
                                  dgallowa@fhcrc.org

                                  Cyrus Ghajar
                                  cghajar@fhcrc.org

                                  Bill Grady
                                  wgrady@fhcrc.org

                                  Sunil Hingorani
                                  srh@fhcrc.org

                                  David MacPherson
                                  dmacpher@fhrc.org

                                  Peter Nelson
                                  pnelson@fhcrc.org

                                  Jerry Radich
                                  jradich@fhcrc.org

                                  Nina Salama
                                  nsalama@fhcrc.org

                                   

                                   

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