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Write a critical review of two of following four topics. Include critical background data, limitations of what is known, and more importantly what is not known. Identify key experiments you might propose to do to support or disprove the concept. About two pages each should be sufficient. Be concise.
On 3 June we will form into four groups according to each topic and each group will have 20-30 minutes to discuss each topic. Everyone will be required to orally argue their case for or against.
Topic 1: DNA damage-induced senescence as a barrier to
cancer.
- An Oncogene-induced DNA damage model for cancer development. Halazonetis TD, Gorgoulis VG, Bartek J.Science. 319(5868):1352-5.2008 Mar 7.
- Tumour biology: Policing of oncogene activity by p53. Efeyan A, Garcia-Cao I, Herranz D, Velasco-Miguel S, Serrano M. Nature. 443(7108):159. 2006 Sep 14.
- Oncogenes and senescence: breaking down in the fast lane. Hemann MT, Narita M. Genes & Development. 21(1):1-5. 2007 Jan 1.
Topic 2: The role of epigenetics in cancer.
- The history of cancer epigenetics. Feinberg AP, Tycko B. Nature Reviews. Cancer. 4(2):143-53. 2004 Feb.
- The epigenetic progenitor origin of human cancer. Feinberg AP, Ohlsson R, Henikoff S. Nature Reviews. Genetics. 7(1), 21-33. 2006 Jan.
Topic 3: Mutator phenotype and cancer.
- Cancers exhibit a mutator phenotype: clinical implications. Loeb LA, Bielas JH, Beckman, RA. Cancer Research. 68(10): 3551-7. 2008 May 15.
- Genetic instability is not a requirement for tumor development. Bodmer W. Cancer Research. 68(10):3558-61. 2008 May 15.
Topic 4: Stem cells and cancer
- Cancer stem cells: an old idea—a paradigm shift. Wicha MS, Liu S, Dontu G. Cancer Research. 66(4):1883-90. 2006 Feb 15.
- Identifying cancer stem cells in solid tumors: case not proven. Hill RP. Cancer Research. 66(4):1891-5. 2006 Feb 15.
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Lecture 1 - 5/6/08 - Chris Kemp
RAS and p53
- An oncogene-induced DNA damage model for cancer development.
Halazonetis TD. Gorgoulis VG. Bartek J. Science. 319(5868):1352-5, 2008 Mar 7 - Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Roberts PJ. Der CJ. Oncogene. 26(22):3291-310, 2007 May 14
- p53 in health and disease. Vousden KH. Lane DP. Nature Reviews Molecular Cell Biology. 8(4):275-83, 2007 Apr.
- Divorcing ARF and p53: an unsettled case. Sherr CJ. Nature Reviews. Cancer. 6(9):663-73, 2006 Sep.
- Multistep skin cancer in mice as a model to study the evolution of cancer cells. Kemp CJ. Seminars in Cancer Biology. 15(6):460-73, 2005 Dec.
- Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Repasky GA. Chenette EJ. Der CJ. Trends in Cell Biology. 14(11):639-47, 2004 Nov.
- RHO-GTPases and cancer. Sahai E. Marshall CJ. Nature Reviews. Cancer. 2(2):133-42, 2002 Feb.
- Live or let die: the cell's response to p53 Vousden KH. Lu X. Nature Reviews. Cancer. 2(8):594-604, 2002 Aug.
- Oncogene-induced senescence pathways weave an intricate tapestry. Yaswen P. Campisi J. Cell. 128(2):233-4, 2007 Jan 26.
Lecture 2 - 5/8/08 - Chris Kemp
Inherited susceptibility and tumor suppressor genes
- A census of human cancer genes. Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR. Nature Reviews. Cancer. 4(3):177-83, 2004 Mar
- Patterns of somatic mutation in human cancer genomes. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, et al. Nature. 446(7132):153-8. 2007 Mar 8
- The consensus coding sequences of human breast and colorectal cancers. Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, et al. Science. 314(5797):268-74. 2006 Oct 13
- p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Philipp-Staheli J, Payne SR, Kemp CJ. Experimental Cell Research. 264(1):148-68. 2001 Mar 10
- Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. Philipp-Staheli J, Kim KH, Payne SR, Gurley KE, Liggitt D, Longton G, Kemp CJ. Cancer Cell. 1(4):355-68. 2002 May
- Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM. Genes & Development. 21(14):1731-46. 2007 Jul 15
- The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Chu IM, Hengst L, Slingerland JM. Nature Reviews. Cancer. 8(4):253-67. 2008 Apr
Lecture 3 - 5/13/08 - William Grady
Genetic and epigenetic alterations in colon cancer
-
Epigenetic Changes in Solid and Hematopoietic Tumors.
Toyota, M. and Issa, J-P. (2005) Seminars in Oncology 32:521.
Note: This article is available only in print from FHCRC and UW libraries. Please go to the library to xerox a copy.
- Transforming Growth Factor ß Receptor Type II Inactivation Induces the Malignant Transformation of Intestinal Neoplasms Initiated by Apc Mutation Nina M. Muñoz, Melissa Upton, Andres Rojas, M. Kay Washington, Li Lin, Anna Chytil, Elif G. Sozmen, Blair B. Madison, Ambra Pozzi, Randall T. Moon, Harold L. Moses and William M. Grady. Cancer Research 66, 9837-9844, October 15, 2006.
Lecture 4 - 5/15/08 - Valeri Vasioukhin
Cell adhesion / Wnt signaling
- Wnt/β-Catenin Signaling in Development and Disease Clevers, H. Cell. 127(3):469-480. November 3, 2006
- Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, Chambon P, Huber M, Hohl D, Cano A, Birchmeier W, Huelsken J. Nature. 452(7187):650-3. 2008 Apr 3
Lecture 5 - 5/20/08 - Norm Greenberg
Prostate cancer: from mice to men
- Cumulative Association of Five Genetic Variants with Prostate Cancer Zheng SL, Sun J, Wiklund F, Smith S, Stattin P, Li G, Adami HO, Hsu FC, Zhu Y, Bälter K, et al. New England Journal of Medicine. 358(9):910-9. 2008 Feb 28.
- Targeted Deletion of Hepatic Igf1 in TRAMP Mice Leads to Dramatic Alterations in the Circulating Insulin-Like Growth Factor Axis but Does Not Reduce Tumor Progression Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P. Cancer Research. 68(9):3342-9. 2008 May 1.
- Conditional Deletion of Insulin-like Growth Factor-I Receptor in Prostate Epithelium Sutherland BW, Knoblaugh SE, Kaplan-Lefko PJ, Wang F, Holzenberger M, Greenberg NM. Cancer Research. 68(9):3495-504. 2008 May 1.
- NCCN Clinical Practice Guidelines in Oncology - Prostate Cancer National Comprehensive Cancer Network. v.1. 2008 Feb 21.
Lecture 6 - 5/22/08 - Carla Grandori
Oncogene networks to identify cancer targets
- The c-Myc target gene network Dang CV, O'Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F. Seminars in Cancer Biology. 16(4): 253-64. 2006 Aug.
- The MAX-interacting transcription factor network Hurlin PJ, and Huang J. Seminars in Cancer Biology. 16(4): 265-74. 2006 Aug.
- c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, and White RJ. Nature Cell Biology. 7(3):311-8. 2005 Mar.
- Werner syndrome protein limits MYC-induced cellular senescence Grandori C, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, Moser MJ, Oshima J, Russell DW, Swisshelm K, Frank S, Amati B, Dalla-Favera R, Monnat RJ Jr. Genes & Development. 17(13):1569-74. 2003 Jul 1.
- Non-transcriptional control of DNA replication by c-Myc Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Galloway DA, Gu W, Gautier J, Dalla-Favera R. Nature. 448(7152):445-51. 2007 Jul 26.
- A loss-of-function RNA interference screen for molecular targets in cancer. Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G, Lam LT, Dave S, Yang L, Powell J, Staudt LM. Nature. 441(7089):106-10. 2006 May 4.
- Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions Bartz SR, Zhang Z, Burchard J, Imakura M, Martin M, Palmieri A, Needham R, Guo J, Gordon M, Chung N, et al. Molecular and Cellular Biology. 26(24):9377-86. 2006 Dec.
Lecture 7 - 5/27/08 - Brian Reid
Evolution of Barrett's esophageal cancer
- NSAIDs Modulate CDKN2A, TP53, and DNA Content Risk for Progression to Esophageal Adenocarcinoma Galipeau PC, Li X, Blount PL, Maley CC, Sanchez CA, Odze RD, Ayub K, Rabinovitch PS, Vaughan TL, Reid BJ. PLOS Medicine. 4(2):e67. 2007 Feb.
Lecture 8 - 5/29/08 - Toshi Taniguchi
BRCA1/2 and chemotherapy
- Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers Sakai W, Swisher EM, Karlan BY, Agarwal MK, Higgins J, Friedman C, Villegas E, Jacquemont C, Farrugia DJ, Couch FJ, Urban N, Taniguchi T. Nature. 451(7182):1116-20. 2008 Feb 28;
- Resistance to therapy caused by intragenic deletion in BRCA2 Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A. Nature. 451(7182):1111-5. 2008 Feb 28
- Cancer: crossing over to drug resistance. Livingston DM, Silver DP. Nature. 451(7182):1066-7. 2008 Feb 28
Lecture 10 - 6/5/08 - Peggy Porter
Pathology and genomics in breast cancer
- A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Richard M. Neve et al. Cancer Cell. 10: 515-527. 2006
- Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Therese Sørlie, et al. PNAS 98(19):10869-10874.
CONJ 539 Contact
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Contact Info:
Phone: 206-667-4252
Fax: 206-667-5815
Email Me
View My Website / Blog
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William Grady - wgrady@fhcrc.org
Carla Grandori - cgrandor@fhcrc.org
Norman Greenberg - ngreenberg@fhcrc.org
Chris Kemp - cjkemp@fhcrc.org
Peggy Porter - pporter@fhcrc.org
Brian Reid - bjr@fhcrc.org
Toshi Tanaguchi - ttaniguc@fhcrc.org
Valeri Vasioukhin - vvasiouk@fhcrc.org
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