Time & Location
September 29-November 1, 2011
Tuesday and Thursday
FHCRC Campus, Weintraub Bldg.
Grading is based on class participation and a problem set assigned at the end of the class. Assigned papers will be presented by students - everyone should be ready to present.
Online Reference Books
See the E-Reserves page (yellow tab above) for the class reading assignments.
Thursday, Sep 29, 2011: (Roth)Physiological limits
Tuesday, Oct 4, 2011: (Gottschling)General concepts in metabolism control; glycolysis, TCA cycle, and oxidative phosphorylation
Thursday, Oct 6, 2011: (Roth)Metabolic flexibility
Tuesday, Oct 11, 2011: (Gottschling)How cells sense and deal with rich and lean environments
Thursday, Oct 13, 2011: (Roth)Allometric scaling
Tuesday, Oct 18, 2011: (Gottschling)How metabolism creates ecological communities
Thursday, Oct 20, 2011: (Roth)Oscillation in biology
Tuesday, Oct 25, 2011: (Gottschling)Aging and metabolic damage
Thursday, Oct 27, 2011: (Roberts)The Warburg effect
Tuesday, Nov 1, 2011: (Hockenbery)The metabolic needs of cancer cells
Nicholson Metabolic Pathways Wall Chart
This is a large wall chart of "central" metabolism with an emphasis on glycolysis, the TCA cycle and Oxidative phosphoryaltion. It provides a "big pictue" perspective.
IUBMB Nicholson minimaps
These are a series of "mini-maps" that separate various portions of overall metabolism into simpler modules for focused discussion of regulation, energy production, etc.
KEGG Pathway Database
Wiring diagrams of molecular interactions, reactions, and relationships. Can be constrained to metabolic pathways in specfic organsims.