Time & Location
September 26 - October 29, 2013
Tuesday and Thursday
FHCRC Campus, Weintraub Bldg.
Grading is based on class participation and regular presentation of assigned papers. In addtion, one or two problem sets may be assigned to reinforce concepts.
Online Reference Books
See the E-Reserves page (yellow tab above) for the class reading assignments.
Thursday, Sep 26, 2013: (Gottschling)General concepts in metabolism control
Tuesday, Oct 1, 2013: (Gottschling)Glycolysis, TCA cycle and oxidative phosphorylation
Thursday, Oct 3, 2013: (Perez-Olsen)The biosynthesis and role of lipids and fatty acids in biology
Tuesday, Oct 8, 2013: (Valente)How cells sense and deal with rich and lean environments
Thursday, Oct 10, 2013: (Entwisle)Links between oxygen, respiration and nutrients
Tuesday, Oct 15, 2013: (Samanas)ROS and the immune system
Thursday, Oct 17, 2013: (Valente)Oncogene-induced senescence
Tuesday, Oct 22, 2013: (Entwisle)Metabolism in our guts...
Thursday, Oct 24, 2013: (Samanas)Mitochondrial "flashing"
Tuesday, Oct 29, 2013: The Final EventA difference of opinion in how antibiotics work.
Nicholson Metabolic Pathways Wall Chart
This is a large wall chart of "central" metabolism with an emphasis on glycolysis, the TCA cycle and Oxidative phosphorylation. It provides a "big picture" perspective.
IUBMB Nicholson minimaps
These are a series of "mini-maps" that separate various portions of overall metabolism into simpler modules for focused discussion of regulation, energy production, etc.
KEGG Pathway Database
Wiring diagrams of molecular interactions, reactions, and relationships. Can be constrained to metabolic pathways in specific organisms.
ExPASy Metabolic Pathways Chart
The original metabolic wall chart, now converted into a digital format with informative links.