Time & Location
September 29-November 1, 2011
Tuesday and Thursday
3:20-4:40 p.m.
FHCRC Campus, Weintraub Bldg.
Room B1-072/074
Grading
Grading is based on class participation and a problem set assigned at the end of the class. Assigned papers will be presented by students - everyone should be ready to present.
Online Reference Books
Lectures
See the E-Reserves page (yellow tab above) for the class reading assignments.
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Thursday, Sep 29, 2011: (Roth)Physiological limits
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Tuesday, Oct 4, 2011: (Gottschling)General concepts in metabolism control; glycolysis, TCA cycle, and oxidative phosphorylation
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Thursday, Oct 6, 2011: (Roth)Metabolic flexibility
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Tuesday, Oct 11, 2011: (Gottschling)How cells sense and deal with rich and lean environments
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Thursday, Oct 13, 2011: (Roth)Allometric scaling
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Tuesday, Oct 18, 2011: (Gottschling)How metabolism creates ecological communities
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Thursday, Oct 20, 2011: (Roth)Oscillation in biology
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Tuesday, Oct 25, 2011: (Gottschling)Aging and metabolic damage
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Thursday, Oct 27, 2011: (Roberts)The Warburg effect
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Tuesday, Nov 1, 2011: (Hockenbery)The metabolic needs of cancer cells
CONJ 552 Faculty
Course Instructors:
Dan Gottschling
FHCRC; UW Genome Sciences
dgottsch@fhcrc.org
Mark Roth
FHCRC; UW Biochemistry
mroth@fhcrc.org
Guest Lecturers:
Jim Roberts
FHCRC
jroberts@fhcrc.org
David Hockenbery
FHCRC
dhockenb@fhcrc.org
Web-linked Resources
Nicholson Metabolic Pathways Wall Chart
This is a large wall chart of "central" metabolism with an emphasis on glycolysis, the TCA cycle and Oxidative phosphoryaltion. It provides a "big pictue" perspective.
IUBMB Nicholson minimaps
These are a series of "mini-maps" that separate various portions of overall metabolism into simpler modules for focused discussion of regulation, energy production, etc.
KEGG Pathway Database
Wiring diagrams of molecular interactions, reactions, and relationships. Can be constrained to metabolic pathways in specfic organsims.
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