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Conj 539 Biological Basis of Neoplasia   Tags: conj539, neoplasia, taniguchi, vasioukhin  

Conjoint 539 MCB program Core Course Module Spring Quarter: April 1 - June 5, 2014
Last Updated: Apr 30, 2014 URL: http://libguides.fhcrc.org/neoplasia Print Guide RSS UpdatesEmail Alerts

Lecture Schedule Print Page
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Time & Location

April 1 - June 5, 2014
Tuesday and Thursday

3:20-4:40 p.m.
FHCRC Weintraub bldg
Room B1-072/074

 

Course Textbook

Cover Art
The Biology of Cancer - Robert A. Weinberg
Call Number: QZ 202 W423b 2014
ISBN: 9780815342205
Publication Date: 2013-05-16

Recommended Readings

The Emperor of all Maladies by Siddhartha Mukherjee

The Molecular Basis of Cancer by John Mendelsohn MD et al.


  • Nature Milestones in Cancer
    The Milestones are a series of specially written articles, which highlight the most influential discoveries in the field of cancer over the past century. Milestones in Cancer also comprises a Collection of selected review-type articles and an online-only NPG library of recent research papers and review content organized according to contributing journal.
  • Nature Reviews Cancer
 

Conj 539 Course Description

This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis.

The latest state of the art research in Cancer Biology will be presented by invited scientists, experts in their relevant field. The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.  (3 credits)

Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

Enrollment in the course is limited to 20 students.

 

Lecture 1 - April 1, 2014

Introduction: Genetic basis of cancer

Valera Vasioukhin

Readings (copies available in eReserves)

Hallmarks of Cancer: The Next Generation
Hanahan, D. and Weinberg, R.
Cell 2011;144(5): 646-674

The Biology of Cancer. Weinberg (on reserve in Arnold Library)

     

    Lecture 2 - April 3, 2014

    Oncogenes

    Valera Vasioukhin

    Readings (copies available in eReserves)

    Hallmarks of Cancer: The Next Generation
    Hanahan, D. and Weinberg, R.
    Cell 2011;144(5): 646-674

    The Biology of Cancer. Weinberg (on reserve in Arnold Library)

       

      Lecture 3 - April 8, 2014

      Tumor Suppressors

      Toshiyasu Taniguchi

      Readings (copies available in eReserves)

      Hallmarks of Cancer: The Next Generation
      Hanahan, D. and Weinberg, R.
      Cell 2011;144(5): 646-674

      The Biology of Cancer. Weinberg (on reserve in Arnold Library)

         

        Lecture 4 - April 10, 2014

        Molecular Basis of Cancer Therapy and Resistance

        Toshiyasu Taniguchi

        Readings (copies available in eReserves)

        Hallmarks of Cancer: The Next Generation
        Hanahan, D. and Weinberg, R.
        Cell 2011;144(5): 646-674

        The Biology of Cancer. Weinberg (on reserve in Arnold Library)

           

          Lecture 5 - April 15, 2014

          Prostate Cancer

          Peter Nelson

          Readings (copies available in eReserves) 

          REVIEW :   Molecular genetics of prostate cancer: new prospects for old challenges
          Michael M. Shen and Cory Abate-Shen
          Genes & Development, 2010;  24:1967–2000

          RESEARCH PAPER: Balbas MD, Evans MJ, Hosfield DJ, Wongvipat J, Arora VK, Watson PA, et al. Overcoming mutation-based resistance to antiandrogens with rational drug design. Elife 2013;2:e00499.

          (This paper will be presented in a student-led literature review session on May 22, Thursday)

             

            Lecture 6 -April 17, 2043

            Myc Oncogene

            Bob Eisenman

            Reading (copies available in eReserves)

            REVIEW: Conacci-Sorrell M, McFerrin L, Eisenman RN. An overview of MYC and its interactome. Cold Spring Harb Perspect Med 2014;4(1):a014357.

             RESEARCH PAPER: Lin CY, Loven J, Rahl PB, Paranal RM, Burge CB, Bradner JE, et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 2012;151(1):56-67.

            (This paper will be presented in a student-led literature review session on May 15, Thursday)

               

              Lecture 7 - April 22, 2014

              Cell Cycle and Ubiquitin

              Bruce Clurman

              Readings (copies available in eReserves)

              REVIEW: Bassermann F, Eichner R, Pagano M. The ubiquitin proteasome system — Implications for cell cycle control and the targeted treatment of cancer. Biochimica et Biophysica Acta 2014; 150–162.

                 

                Lecture 8 - April 24, 2014

                Lung Cancer and Rb

                David MacPherson

                Readings (copies available in eReserves)

                 REVIEW: Kwon MC, Berns A. Mouse models for lung cancer. Mol Oncol 2013;7(2):165-77.

                RESEARCH PAPER: Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, et al. The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 2013;23(4):527-40.

                (This paper will be presented in a student-led literature review session on June 5.)

                   

                  Lecture 9 - April 29, 2014

                  Molecular Pathogenesis of Colorectal Cancer

                  Bill Grady

                  Readings (copies available in eReserves)

                   REVIEW: Roper J, Hung KE. Molecular Mechanisms of Colorectal Carcinogenesis. In: Haigis KM, editor. Molecular Pathogenesis of Colorectal Cancer; 2013. p. 25-65.

                  RESEARCH PAPER: Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457(7229):608-11.

                  (This paper will be presented in a student-led literature review session on June 3)

                     

                    Lecture 10 - May 1, 2014

                    HPV and squamous cell carcinoma

                    Denise Galloway

                    Readings (copies available in eReserves)

                    REVIEW: Gillison ML, Castellsague X, Chaturvedi A, Goodman MT, Snijders P, Tommasino M, Arbyn M, Franceschi S. Eurogin Roadmap: comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix. Int J Cancer 2014;134(3):497-507.

                    RESEARCH PAPER:  McLaughlin-Drubin ME, Park D, Munger K. Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines. Proc Natl Acad Sci U S A 2013;110(40):16175-80.

                       

                      Lecture 11 - May 6, 2014

                      Metastasis

                      Cyrus Ghajar

                      Readings (copies available in eReserves)

                      REVIEW: Vanharanta S, Massague J. Origins of metastatic traits. Cancer Cell 2013;24(4):410-21.

                      RESEARCH PAPER:  Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012;18(6):883-91.

                      (This paper will be presented in a student-led literature review session on May 13, Tuesday.)

                         

                        Lecture 12 - May 8, 2014

                        Helicobacter pylori and Gastric Cancer
                        Nina Salama

                        Readings (copies available in eReserves)

                         REVIEW: Salama NR, Hartung ML, Muller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol 2013;11(6):385-99.

                        RESEARCH PAPER: Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, et al. Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. Cell Host Microbe 2012;12(6):764-77

                           

                          Lecture 13 - May 13, 2014

                          Literature Review #1

                          Cyrus Ghajar's choice (Metastasis)

                           Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012;18(6):883-91.

                             

                            Lecture 14 - May 15, 2014

                            Literature Review #2

                            Bob Eisenman's choice (Myc)

                             Lin CY, Loven J, Rahl PB, Paranal RM, Burge CB, Bradner JE, et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 2012;151(1):56-67.

                               

                              Lecture 15 - May 20, 2014

                              Mutator Phenotype: Nuclear and mitochondrial mutations in carcinogenesis

                              Jason Bielas

                               Readings (copies available in eReserves)

                              REVIEW:  Kulawiec M, Salk JJ, Ericson NG, Wanagat J, Bielas JH. Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer. Environ Mol Mutagen 2010;51(5):427-39.

                              RESEARCH PAPER: Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 2008;320(5876):661-4.

                                 

                                Lecture 16 - May 22, 2014

                                Literature Review #3

                                Pete Nelson's choice (prostate cancer)

                                 Balbas MD, Evans MJ, Hosfield DJ, Wongvipat J, Arora VK, Watson PA, et al. Overcoming mutation-based resistance to antiandrogens with rational drug design. Elife 2013;2:e00499.

                                   

                                  Lecture 17 - May 27, 2014

                                  Literature Review #5

                                  David MacPherson's choice (lung cancer)

                                   Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, et al. The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 2013;23(4):527-40.

                                   

                                     

                                    Lecture 18 - May 29, 2014

                                    Hematopoetic Malignancies

                                    Jerry Radich

                                     Readings (copies available in eReserves)

                                    REVIEW:  Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011;29(5):475-86.

                                    RESEARCH PAPER:

                                    Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, et al. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med 2013;368(19):1781-90.

                                    Anderson K, Lutz C, van Delft FW, Bateman CM, Guo Y, Colman SM, et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 2011;469(7330):356-61.

                                    Haibe-Kains B, El-Hachem N, Birkbak NJ, Jin AC, Beck AH, Aerts HJ, et al. Inconsistency in large pharmacogenomic studies. Nature 2013;504(7480):389-93.

                                       

                                      Lecture 19 - June 3, 2014

                                      Literature Review #4

                                      Bill Grady's choice (colorectal cancer)

                                      Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457(7229):608-11.

                                         

                                        Lecture 20 - June 5, 2014

                                        Pancreatic Cancer

                                        Sunil Hingorani


                                        Readings (copies available in eReserves)

                                        REVIEW: Hingorani SR, Potter JD. Pancreas cancer meets the thunder god. Sci Transl Med 2012;4(156):156ps21.

                                        RESEARCH PAPER: Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012;21(3):418-29.

                                         

                                           

                                          Course Instructors

                                          Course organizers

                                          Valera Vasioukhin
                                          vvasiouk@fhcrc.org

                                          Toshi Taniguchi
                                          ttaniguc@fhcrc.org

                                          Lecturers

                                          Jason Bielas
                                          jbielas@fhcrc.org

                                          Bruce Clurman
                                          bclurman@fhcrc.org

                                          Bob Eisenman
                                          eisenman@fhcrc.org

                                          Denise Galloway
                                          dgallowa@fhcrc.org

                                          Cyrus Ghajar
                                          cghajar@fhcrc.org

                                          Bill Grady
                                          wgrady@fhcrc.org

                                          Sunil Hingorani
                                          srh@fhcrc.org

                                          David MacPherson
                                          dmacpher@fhrc.org

                                          Peter Nelson
                                          pnelson@fhcrc.org

                                          Jerry Radich
                                          jradich@fhcrc.org

                                          Nina Salama
                                          nsalama@fhcrc.org

                                           

                                           

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