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Recommended Book
The Biology of Cancer - R.A. Weinberg
ISBN/ISSN: 0815340788
Readings for Lecture 1
Lecture 1 - 5/5/09 - Chris Kemp
Multistage cancer; putting oncogenes and tumor suppressor genes in context
- An oncogene-induced DNA damage model for cancer development.
Halazonetis TD. Gorgoulis VG. Bartek J. Science. 319(5868):1352-5, 2008 Mar 7 - Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Roberts PJ. Der CJ. Oncogene. 26(22):3291-310, 2007 May 14
- p53 in health and disease. Vousden KH. Lane DP. Nature Reviews Molecular Cell Biology. 8(4):275-83, 2007 Apr.
- Divorcing ARF and p53: an unsettled case. Sherr CJ. Nature Reviews. Cancer. 6(9):663-73, 2006 Sep.
- Multistep skin cancer in mice as a model to study the evolution of cancer cells. Kemp CJ. Seminars in Cancer Biology. 15(6):460-73, 2005 Dec.
- Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Repasky GA. Chenette EJ. Der CJ. Trends in Cell Biology. 14(11):639-47, 2004 Nov.
- RHO-GTPases and cancer. Sahai E. Marshall CJ. Nature Reviews. Cancer. 2(2):133-42, 2002 Feb.
- Live or let die: the cell's response to p53 Vousden KH. Lu X. Nature Reviews. Cancer. 2(8):594-604, 2002 Aug.
- Oncogene-induced senescence pathways weave an intricate tapestry. Yaswen P. Campisi J. Cell. 128(2):233-4, 2007 Jan 26.
Readings for Lecture 2
Lecture 2 - 5/7/09 - Chris Kemp
Inherited susceptibility and tumor suppressor genes
- A census of human cancer genes. Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR. Nature Reviews. Cancer. 4(3):177-83, 2004 Mar
- Patterns of somatic mutation in human cancer genomes. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, et al. Nature. 446(7132):153-8. 2007 Mar 8
- The consensus coding sequences of human breast and colorectal cancers. Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, et al. Science. 314(5797):268-74. 2006 Oct 13
- p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Philipp-Staheli J, Payne SR, Kemp CJ. Experimental Cell Research. 264(1):148-68. 2001 Mar 10
- Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. Philipp-Staheli J, Kim KH, Payne SR, Gurley KE, Liggitt D, Longton G, Kemp CJ. Cancer Cell. 1(4):355-68. 2002 May
- Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM. Genes & Development. 21(14):1731-46. 2007 Jul 15
- The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Chu IM, Hengst L, Slingerland JM. Nature Reviews. Cancer. 8(4):253-67. 2008 Apr
Readings for Lecture 3
Lecture 3 - 5/12/09 - Bob Eisenman
Myc and transformation
- Myc's broad reach Eilers, M., Eisenman, R.N. (2008) Genes and Dev 22:2755-2766
- Myc influences global chromatin structure Knoepler et al. (2006) EMBO Jour 25: 2723-2734
- Distinct Thresholds Govern Myc's Biological Output In Vivo Murphy et. al. (2008) Cancer Cell 14: 447-457
Readings for Lecture 4
Lecture 4 - 5/14/09 - Jon Cooper
Tyrosine kinases and cancer
Discussion paper for class:
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression
Lahlou et al. (2007) Proc Natl Acad Sci U S A. 104(51):20302-7.
Overview:
The hunting of the Src
Martin, G.S. (2001) Nat Rev Mol Cell Biol. 2(6):467-75
Papers on genes that may cooperate with Src to cause transformation:
The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src
Oneyama et al. (2008) Mol Cell. 30(4):426-36.
Restriction of Src activity by Cullin-5
Laszlo, G.S. and Cooper, J.A. (2009) Curr Biol. 19(2):157-62
Readings for Lecture 5
Lecture 5 - 5/19/09 - William Grady
Genetic and epigenetic alterations in colon cancer
- Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis Grady, W. M., and Carethers, J.M. (2008) Gastroenterology 135: 1079-1099
- Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer Schuebel et al (2007) PLoS Genetics 3:e157
- The Consensus Coding Sequences of Human Breast and Colorectal Cancers Tobias Sjöblom, et al. (2006) Science 314: 268-274
Readings for Lecture 6
Lecture 6 - 5/21/09 - Brian Reid
Evolution of Barrett's esophageal cancer
- The significance of unstable chromosomes in colorectal cancer Rajagopalan et al (2003) Nature Reviews Cancer 3:695
- Genetic clonal diversity predicts progression to esophageal adenocarcinoma Maley et al (2006) Nature Genetics 38: 468
- NSAIDs Modulate CDKN2A, TP53, and DNA Content Risk for Progression to Esophageal Content Risk for Progression to Esophageal Galipeau et al (2007) PLoS Medicine 4: 0342 (e67)
- Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression Xiaohong et al (2008) Cancer Prev Res 1:413
Readings for Lecture 7
Lecture 7 - 5/26/09 - Valeri Vasioukhin
Cell adhesion/Wnt signaling
- Wnt/β-Catenin Signaling in Development and Disease Clevers, H. (2006) Cell 127:469
- Crypt stem cells as the cells-of-origin of intestinal cancer Barker et al (2009) Nature 457:608
Readings for Lecture 8
Lecture 8 - 5/28/09 - Pete Nelson
Genetics and biology of prostate cancer
- Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer Tomlins et al (2005) Science 310: 644
- The Influence of Finasteride on the Development of Prostate Cancer Thompson et al (2003) NEJM 349:211
- The Influence of Finasteride on the Development of Prostate Cancer Therapy Chen et al (2004) Nature Medicine 10:33
Readings for Lecture 9
Lecture 9 - 6/2/09 - Carla Grandori
High throughput screening to identify new therapeutics for cancer
Readings for Lecture 10
Lecture 10- 6/4/09 - Toshi Tanaguchi
Brca1/Brca2 pathway and chemotherapy
- Cancer: Crossing over to drug resistance Livingston et al (2008) Nature 451: 1066-1067
- Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers Sakai et al (2008) Nature 451: 1116-1120.
CONJ 539 Contact |
Chris KempCONJ 539 Faculty
Jon Cooper - jcooper@fhcrc.org
Bob Eisenman - eisnenman@fhcrc.org
William Grady - wgrady@fhcrc.org
Carla Grandori - cgrandor@fhcrc.org
Chris Kemp - cjkemp@fhcrc.org
Pete Nelson - pnelson@fhcrc.org
Brian Reid - bjr@fhcrc.org
Toshi Tanaguchi - ttaniguc@fhcrc.org
Valeri Vasioukhin - vvasiouk@fhcrc.org
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