Announcements
Class will next be offerred Autumn Quarter 2010.
Class size is limited to 24 students in the MCB, Microbiology, or Pathobiology Ph.D programs.
The current content on this website describes the material covered Autumn Quarter 2008.
Grading: 50% of your grade is based on class participation, 25% on the in-class exam, and 25% on the final project.
Email Michael Emerman (memerman@fhcrc.org) for questions.
Off-Campus?
If you're off-campus (either UW or FHCRC), click on the appropriate links in this box below before trying to access full text course readings.
Once you've logged in, use your "back" button to return to this page and click on the links to the readings.
FHCRC/MCB students (sign in with your FHCRC library card login and password)
UW students (sign in with your UW NetID login)
How to...
Click on the date/title of the lecture in the boxes below to download a Pdf copy of the lecture.
Lectures will be ready for downloading by the day before the lecture.
Click on the link for the Dicussion papers and you will be routed to the article at the journal's website. You should be able to download a Pdf of the Discussion paper from there. See the "Off-Campus?" box on your left for accessing papers when you are not on the UW or FHCRC campuses.
Use the "Comments" in each box to ask a question about that Lecture or Discussion paper and I will try to cover it during class.
Lecture 7
Thursday 10/16/08: Filoviruses (Ebola)
Michael Emerman
- Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus Science 7 October 2005:
Vol. 310. no. 5745, pp. 77 - 80
Lecture 8
Tuesday 10/21/08: Picornaviruses (Polio)
Michael Emerman
- Wave-like spread of Ebola Zaire PLoS Biol. 2005 Nov;3(11):e371
Lecture 9
Thursday 10/23/08: Innate Immunity and Viral Control
Michael Gale
- Virus Attenuation by Genome-Scale Changes in Codon Pair Bias Science 27 June 2008:
Vol. 320. no. 5884, pp. 1784 - 1787
Lecture 10
Tuesday 10/28/08: Hepatitis C Virus
Michael Gale
- Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections Nature Medicine
Published online: 14 September 2008
Lecture 11
Thursday 10/30/08: Coronaviruses (SARS)
Michael Emerman
The Discussion paper for 10/30/08 will be the Nipha virus receptor paper (from lecture 6) that we didn't get to before.
Lecture 12
Melody Li
For a copy of Melody Li's +strand RNA virus summary, click here
- A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice PLoS Pathog 3(1): e5 2007
Lecture 13
Thursday 11/6/08: Papillomaviruses
Denise Galloway
- A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential PLoS Pathog 3(12): e201.
In class exam
Thursday 11/13/08
Copy of exam in previous class posted below. The exam this year will be similar except that there will be fewer questions and you will need to answer all of them. Only spend 9-10 minutes per quesiton, so you don't need to write a lot.
Open notes. if you are handwriting your answers, bring paper and write your name on all of the sheets. If you are typing your answers, charge the batteries in your laptop and set up a file with your name on it.
Lecture 14
Tuesday 11/18/08: Hepatitis B Virus
Maxine Linial
No discussion paper for today. Class starts at 2PM.
Start your final projects!
Lecture 15
Michael Emerman
No discussion paper for today. However, class still starts at 1:30PM
Work on your final projects!
Lecture 16
Tuesday 11/25/08: Pox Viruses (Smallpox)
Michael Emerman
- Conversion of the BASE Prion Strain into the BSE Strain: The Origin of BSE? PLoS Pathog. 2007 Mar;3(3):e31.Click here to read
Lecture 17
Tuesday 12/02/08: Herpes Simplex Virus
Keith Jerome
- Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells Science. 2008 Apr 25;320(5875):531-5
Lecture 18
Thursday 12/04/08: Dengue Virus
Molly OhAinle
Final project workshop today before the lecture. Bring your work in progress and we will break into groups to discuss them.
Final Projects
Due Wednesday Dec. 10 by 3PM.
If your file is less than 10MB, then there should be no problem to email it to me. Please use the words "MCB532 final project" in the subject line. I will send you a reply email to let you know I received it.
If you are worried about email, or if your file size is large, then feel free to bring it by my office (C2-019 in the Hutchinson Building) on a flash drive and I will load it onto my computer.
If you are a 1st Yr MCB student, you can also give me your file on a flash drive at the rotation talk lunch on Tuesday.
Course Resources
- Microbiology Bytes Great website for specific information about virus families with links to new papers and good illustrations. Use this website as an entry point for looking up questions for class or for reviewing the lectures
- Virus Replication Animations
Animated schematics of virus replication of many major virus classes. I will be showing some of these during class, but you can review them here as well. - Universal Virus Database Virus database. Very complete, but somewhat hard to navigate.
Virus-related Books
And the band played on - R Shilts
ISBN/ISSN: 0312374631
How the cows turned mad : unlocking the mysteries of mad cow disease / - M Schwartz
ISBN/ISSN: 0520243374
Polio: an American Story - DM Oshinsky
ISBN/ISSN: 0195152948
The great influenza - JM Barry
ISBN/ISSN: 0143036491
The greatest killer - DR Hopkins
ISBN/ISSN: 0226351688
China Syndrome: The True Story of the 21st Century's First Great Epidemic - K.T. Greenfeld
ISBN/ISSN: 0060587229
The hot zone - R Preston
ISBN/ISSN: 0385479565
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