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Conj529 Cell Migration   Tags: conj529, cooper, moens  

This course covers mechanisms of cell migration, from the basic subcellular events that generate and stabilize cellular protrusions to the diffusible attractants and repellants that orient migration.
Last Updated: Feb 14, 2014 URL: http://libguides.fhcrc.org/cellmigration Print Guide RSS UpdatesEmail Alerts

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Time & Location

Feb 11 - March 13, 2014
Tuesday and Thursday

3:20-4:40 p.m.
Room B1-072
FHCRC Campus, Weintraub Bldg.

 

Student Presentations

Feb. 18 paper #1: Gabe Butterfield

Feb. 18 paper #2: Anthony Castanza

Feb. 20 paper #1: Lori Koch

Feb. 20 paper #2: Melissa Stele-Ogus

Feb. 27 paper #1: Nyssa Samanas

Feb. 27 paper #2: Melissa Eng

March 6 paper #1: Catriona Wagner

March 6 paper #2: Joshua Swore

March 13 paper #1: Claire Williams

March 13 paper #2: Gabby Barsh

 

Grading

Grading is based:

  • 50% on presentation (lit review) and class participation during other people's presentations.

Each student will be assigned one research paper to present. Presentations should be timed for 20 min maximum, picking on the major points. Do not feel that you need to explain every panel of every figure. All students must read each paper. and are expected to come to class ready to discuss when called on. This means reading the paper in order to understand it, and looking up references if there are points you do not understand.

  • 50% on your written assignment

The written assignment is a 2-page Nature style "mini-review" on any recent paper(s) on cell migration. The papers should not be one of the papers discussed in lit review and review approval by Jon or Cecilia. The assignment is due on Tues March 13.

 

Class Schedule: Week 1

Week 1:  Cell biology of migration

Tue Feb 11: Cell biology of migration: actin dynamics, adhesion and force generation (Jon)

Thur Feb 13: Polarity and direction sensing - Jon

Lecture slides and readings in eReserves

 

Week 2

Week 2: Cell biology of migration literature reviews

Tue Feb 18: literature review.

Thur Feb 20: literature review.

Lecture slides and readings in eReserves

     

    Week 3

    Week 3: Cancer cells and the metastatic phenotype

    Tue Feb 25: epithelial-mesenchymal transition, invadopodia, tumor microenvironment influences (Cecilia)

    Thur Feb 27: literature review

    Lecture slides and readings in eReserves

       

      Week 4

      Week 4: Directed cell migration in development : contact-dependent and diffusible cues

      Tue March 4: neurons and growth cones

      Thur March 6: literature review

      Lecture slides and readings in eReserves

         

        Week 5

        Week 5: Collective cell migration in development

        Tue March 11: convergent extension, neural crest, lateral line, border cells (Cecilia)

        Thur March 13: literature review

        Lecture slides and readings in eReserves

           

          Conj 529 Faculty

          Course Instructors:

          Jon Cooper
          FHCRC Basic Sciences
          jcooper@fhcrc.org

          Cecilia Moens
          FHCRC Basic Sciences
          cmoens@fhcrc.org

           

          Online Reference Books

          Cover Art
          Molecular Biology of the Cell - Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter
          ISBN: 0815332181
          Publication Date: 2002
          4th edition is available online from NCBI/NLM. Search for topics, browsing is not activated

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